To clarify, Infrastructure, Synthetics, Servers, and Mobile will not be affected by this update. They all use the built-in certificate store.
Java agents may be impacted if you have altered the configuration to the JVM trust store in a way that is not standard. You can read more about configuring your SSL certificates here.
Regarding the node agent: previous to v1.4.0, the Node agent did not have SSL support. Beginning with v1.4.0 the Node agent bundles it’s own certificate bundle, which we have confirmed has the correct root certificate. You can view the node release notes here.